Oseltamivir- and Amantadine-Resistant Influenza Virus A (H1N1)
نویسندگان
چکیده
To the Editor: We previously reported detection of double resistance to oseltamivir and amantadine of influenza virus A (H1N1) in Hong Kong during the first half of 2008 (1). Three different strains of A/Hong Kong/2652/2006-like (clade 2C) viruses that carried the S31N mutation in the matrix (M2) gene associated with amantadine resistance acquired a neuraminidase (NA) gene with CAT→TAT change at position 274 through either reassortment with an oseltamivir-resistant A/Brisbane/59/2007-like (clade 2B) virus or spontaneous H274Y mutation in the NA gene. A clade 2C strain resistant to both oseltamivir and amantadine also was detected in Cambodia in 2007 (2).
منابع مشابه
Simultaneous Detection of Oseltamivir- and Amantadine-Resistant Influenza by Oligonucleotide Microarray Visualization
Presently, the resistance of Influenza A virus isolates causes great difficulty for the prevention and treatment of influenza A virus infection. It is important to establish a drug-resistance detection method for epidemiological study and personalized medicine in the clinical setting. Consequently, a cost-effective oligonucleotide microarray visualization method, which was based on quantum dot-...
متن کاملTriple Combination of Amantadine, Ribavirin, and Oseltamivir Is Highly Active and Synergistic against Drug Resistant Influenza Virus Strains In Vitro
The rapid emergence and subsequent spread of the novel 2009 Influenza A/H1N1 virus (2009 H1N1) has prompted the World Health Organization to declare the first pandemic of the 21st century, highlighting the threat of influenza to public health and healthcare systems. Widespread resistance to both classes of influenza antivirals (adamantanes and neuraminidase inhibitors) occurs in both pandemic a...
متن کاملDelayed emergence of oseltamivir‐resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar
The prevalence and timing of emergence of oseltamivir-resistant seasonal and pandemic influenza A (H1N1) viruses in Myanmar in 2008 and 2009 are described in this report. In 2008, the oseltamivir-resistant seasonal H1N1 virus was detected at a lower rate (6%) and emerged at least 2 months later when compared with neighboring countries. Similarly, the prevalence of pandemic H1N1 virus was low (3...
متن کاملPandemic (H1N1) 2009 influenza.
On 11 June 2009, the World Health Organization declared the first human influenza pandemic since 1968–1969. The responsible virus, pandemic (H1N1) 2009 influenza, is a novel triple-reassortant influenza A virus, incorporating avian, swine and human influenza genes.1 The virus is resistant to the anti-influenza medications, amantadine and rimantadine, but is generally sensitive to the neuraminid...
متن کاملAmantadine-Resistant among Seasonal H1N1 and 2009 Pandemic Isolated of Influenza A Viruses in Iran
Background and Aims: Influenza A viruses are important pathogens for humans especially in pandemic episodes. Two adamantane derivates, amantadine and rimantadine, are used for prophylaxis and treatment of influenza A virus infections. However, single amino acid substitutions in the M2 transmembrane domain which lead to amantadine resistance of these viruses occur at residues 26, 27, 30, 31 or 3...
متن کامل